6.047 Recitation 2 Notes
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چکیده
Why align sequences? Sequence alignments can reveal many things about the functional, structural or evolutionary significance of regions of DNA, RNA or protein. Examples: • The degree of similarity between regions of amino acids can tell us how well that region is conserved, which can provide clues about the structural or functional significance of that region. • The DNA sequence alignment of multiple species can give us clues about how long ago they diverged from a common ancestor, and help us to build us a phylogenetic tree describing the evolutionary history of those species.
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6.047 Recitation 7 Notes
What is linkage disequilibrium? The opposite of linkage equilibrium! Recall Mendel’s 2nd Law: Allels of different genes are passed on independently. When this law holds, there is no correlation between polymorphisms. In this state of random assortment, they are said to be in linkage equilibrium. However, if there are correlated, then they are in linkage disequilibrium. This is the non-random as...
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This is a set of notes and exercises, summarizing and illustrating concepts that we discussed during the first recitation.
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تاریخ انتشار 2017